Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191848 | 0.91 | PTGES (0.50) | PTGESFFAR1ALOX5 | |
| SCHEMBL9476102 | 0.89 | ALOX5 (0.61) | PTGESFFAR1ALOX5CA12CA1 | |
| SCHEMBL9195594 | 0.86 | ACACB (0.46) | PTGESALOX5 | |
| SCHEMBL9193701 | 0.85 | ALOX5 (0.38) | PTGESALOX5 | |
| SCHEMBL9195250 | 0.84 | PTGES (0.53) | PTGESFFAR1ALOX5 | |
| SCHEMBL9192595 | 0.82 | ACACB (0.42) | PTGESFFAR1ALOX5 | |
| SCHEMBL9189969 | 0.82 | ALOX5 (0.43) | PTGESFFAR1ALOX5CA12CA1 | |
| SCHEMBL9192527 | 0.81 | PTGES (0.48) | PTGESALOX5 | |
| SCHEMBL9193097 | 0.80 | PTGES (0.40) | PTGESALOX5 | |
| SCHEMBL9475768 | 0.80 | ALOX5 (0.60) | PTGESFFAR1ALOX5CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468281-B1 | Substituted phenylacetylenes, pharmaceuticals containing them and methods for the preparation of these compounds and pharmaceuticals | GRUENENTHAL GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5202349-A | Lipoxygenase inhibitors, antiasthatics | GRUENENTHAL GMBH (DE) | 1993-04-13 | — | — | US | disclosed |