Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192602 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM5ACHEK2 | |
| SCHEMBL3388523 | 0.83 | BRD4 (0.49) | TGFBR1PTPN5BRD4CREBBP | |
| SCHEMBL3433756 | 0.81 | TGFBR1 (0.45) | TGFBR1PIK3CAFLT3GSK3B | |
| SCHEMBL27906803 | 0.79 | TGFBR1 (0.53) | TGFBR1PIK3CAFLT3GSK3B | |
| SCHEMBL18287886 | 0.79 | PTPN5 (0.47) | SMN1; SMN2PTPN5 | |
| SCHEMBL13343443 | 0.77 | PTPN5 (0.49) | PTPN5 | |
| SCHEMBL9196171 | 0.76 | CA12 (0.41) | SMN1; SMN2KDM5A | |
| SCHEMBL24686234 | 0.76 | TGFBR1 (0.50) | TGFBR1PIK3CAFLT3GSK3B | |
| SCHEMBL3433216 | 0.74 | PSEN1 (0.46) | TGFBR1 | |
| SCHEMBL8337311 | 0.73 | NPC1 (0.52) | TGFBR1FLT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |