Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL919078 | 0.87 | L3MBTL1 (0.35) | ALDH1A1KIF11CHRNA1CHRNGCHRNB1 | |
| SCHEMBL918509 | 0.87 | POLB (0.38) | ALDH1A1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL920338 | 0.86 | ALDH1A1 (0.36) | ALDH1A1KIF11CHRNA1CHRNGCHRNB1 | |
| SCHEMBL919210 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GRIN1GRIN2BCHRNA1CHRNG | |
| SCHEMBL28611458 | 0.70 | CHRNA1 (0.41) | GRIN1GRIN2BCHRNA1CHRNGCHRNB1 | |
| SCHEMBL7879750 | 0.70 | GRIN1 (0.43) | ALDH1A1GRIN1GRIN2BCHRNA1CHRNG | |
| SCHEMBL11246464 | 0.68 | GRIN1 (0.40) | ALDH1A1GRIN1GRIN2BCHRNA1CHRNG | |
| SCHEMBL920192 | 0.67 | HDAC3 (0.55) | HSD11B1RAB9ASMN1; SMN2 | |
| SCHEMBL10837791 | 0.66 | CHRNA1 (0.38) | ALDH1A1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL11248824 | 0.66 | GRIN1 (0.43) | ALDH1A1GRIN1GRIN2BCHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871998-B2 | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity | ASTRAZENECA AB (SE) | 2011-01-18 | — | — | US | disclosed |