Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.32 |
| ▸ | CHRNG | P07510 | 2/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRND | Q07001 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL919078 | 0.89 | L3MBTL1 (0.35) | ALDH1A1SLC6A3SLC6A2CHRNA1CHRNG | |
| SCHEMBL918509 | 0.89 | POLB (0.38) | ALDH1A1SLC6A3SLC6A2CHRNB2CHRNB4 | |
| SCHEMBL919334 | 0.86 | LDHA (0.35) | ALDH1A1MAPK1CHRNA1CHRNGCHRNB1 | |
| SCHEMBL920139 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL27685512 | 0.75 | ALDH1A1 (0.36) | ALDH1A1MAPK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL27704343 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAPK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL28618351 | 0.69 | SLC6A4 (0.39) | ALDH1A1MAPK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL27704339 | 0.68 | APOBEC3A (0.36) | ALDH1A1 | |
| SCHEMBL11231543 | 0.68 | SLC6A4 (0.38) | ALDH1A1MAPK1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL918769 | 0.66 | L3MBTL1 (0.40) | ALDH1A1SLC6A3SLC6A2CHRNA1CHRNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871998-B2 | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity | ASTRAZENECA AB (SE) | 2011-01-18 | — | — | US | disclosed |