Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ANPEP | P15144 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195227 | 0.81 | HTT (0.54) | HTTANPEPALDH1A1SMN1; SMN2 | |
| SCHEMBL9504011 | 0.80 | HTT (0.52) | HTTANPEPCACNA1CSCN5A | |
| SCHEMBL9678877 | 0.79 | TDP1 (0.58) | HTTALDH1A1TSHRCYP2C19ALOX15 | |
| SCHEMBL9504118 | 0.78 | LMNA (0.58) | KMT2ALMNA | |
| SCHEMBL24575947 | 0.75 | HPGDS (0.57) | HTTNPSR1CACNA1CCNR1CA12 | |
| SCHEMBL13480537 | 0.75 | NPSR1 (0.58) | NPSR1CNR1CA12CA1CA2 | |
| SCHEMBL15897742 | 0.73 | CACNA1C (0.61) | HTTANPEPNPSR1CACNA1CSCN5A | |
| SCHEMBL8364624 | 0.72 | NPSR1 (0.54) | NPSR1CNR1CA12CA1CA2 | |
| SCHEMBL9723518 | 0.72 | LMNA (0.54) | KMT2ALMNA | |
| SCHEMBL18415577 | 0.72 | HTT (0.58) | HTTANPEPNPSR1CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | claimed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | claimed |
| EP-0500348-B1 | Disubstituted ureas and thioureas | PHARMACIA SPA (IT) | 1995-05-17 | — | — | EP | disclosed |
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | disclosed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0335374-A2 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |