Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005868 | 0.85 | POLB (0.60) | HTT | |
| SCHEMBL9767143 | 0.83 | LMNA (0.47) | ANPEP | |
| SCHEMBL8321568 | 0.81 | — | — | |
| SCHEMBL9194286 | 0.80 | HTT (0.57) | HTTCACNA1CSCN5AANPEP | |
| SCHEMBL14559554 | 0.77 | PKM (0.49) | — | |
| SCHEMBL13647161 | 0.75 | MTNR1A (0.49) | — | |
| SCHEMBL8532166 | 0.75 | CCR3 (0.56) | — | |
| SCHEMBL9195227 | 0.74 | HTT (0.54) | HTTANPEP | |
| SCHEMBL9848513 | 0.73 | — | — | |
| SCHEMBL8341189 | 0.73 | LMNA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | claimed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | claimed |
| EP-0335374-B1 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1993-06-30 | — | — | EP | disclosed |
| US-5116848-A | N-(((2,6-DISUBSTITUTED)PHENYL)-N-DIARYLALKYL)UREAS AS ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0335374-A2 | N-[[(2,6-disubstituted)phenyl]-N'-diarylalkyl] ureas as antihyperlipidemic and antiatherosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |