Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 5/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113496 | 0.91 | PTGS2 (0.58) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9192919 | 0.87 | PTGS2 (0.59) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9267545 | 0.81 | FAAH (0.44) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8113995 | 0.81 | FAAH (0.53) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8118770 | 0.80 | FAAH (0.53) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8104256 | 0.80 | FAAH (0.63) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8112876 | 0.78 | PTGS2 (0.70) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL29229964 | 0.74 | PTGS2 (0.61) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| Bromide SCHEMBL30874249 | 0.73 | PTGS2 (0.60) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL27338804 | 0.71 | MAPK14 (0.81) | MAPK13MAPK12MAPK11MAPK14FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |