Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8113890 | 0.91 | FAAH (0.51) | FAAHMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9195170 | 0.81 | PTGS2 (0.48) | FAAHMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8104256 | 0.78 | FAAH (0.63) | FAAHMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8113888 | 0.74 | PRKD3 (0.46) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL8113224 | 0.73 | FAAH (0.62) | FAAHGAA | |
| SCHEMBL8104120 | 0.72 | PTGS2 (0.65) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL9194933 | 0.72 | FAAH (0.41) | FAAHALDH1A1MAPTKDM4EGAA | |
| SCHEMBL8118770 | 0.70 | FAAH (0.53) | FAAHMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8113496 | 0.70 | PTGS2 (0.58) | FAAHMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8113995 | 0.69 | FAAH (0.53) | FAAHMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |