Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765055 | 0.81 | SOAT1 (0.63) | SOAT1 | |
| SCHEMBL10891868 | 0.80 | SOAT1 (0.70) | SOAT1 | |
| SCHEMBL9784436 | 0.76 | SOAT1 (0.59) | RAB9APOLBSOAT1MMP1MMP2 | |
| SCHEMBL9765032 | 0.76 | MMP1 (0.48) | ULK1RAB9APOLBSOAT1MMP1 | |
| SCHEMBL9192201 | 0.73 | ALDH1A1 (0.49) | POLBALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9265603 | 0.71 | HTT (0.68) | ULK1RAB9APOLBSOAT1MMP1 | |
| SCHEMBL9257327 | 0.71 | SOAT1 (0.86) | SOAT1 | |
| SCHEMBL10587602 | 0.71 | SOAT1 (0.86) | SOAT1 | |
| SCHEMBL9784452 | 0.71 | SOAT1 (0.77) | POLBSOAT1MMP1MMP2MMP9 | |
| SCHEMBL9256286 | 0.71 | SOAT1 (0.74) | SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0500348-B1 | Disubstituted ureas and thioureas | PHARMACIA SPA (IT) | 1995-05-17 | — | — | EP | disclosed |
| US-4994465-A | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |