Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD4 | P21917 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388487 | 0.82 | DRD4 (0.69) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL1388300 | 0.81 | DRD2 (0.56) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL9202150 | 0.80 | DRD2 (0.57) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL1388664 | 0.75 | DRD4 (0.60) | DRD2DRD4DRD3 | |
| SCHEMBL9195743 | 0.75 | DRD2 (0.55) | DRD2DRD4DRD3MAPTALDH1A1 | |
| SCHEMBL9202145 | 0.74 | SIGMAR1 (0.55) | DRD2DRD4DRD3OPRM1KMT2A | |
| SCHEMBL9199928 | 0.72 | MEN1 (0.60) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL1388639 | 0.69 | DRD2 (0.70) | DRD2DRD4DRD3OPRM1KMT2A | |
| SCHEMBL1388432 | 0.68 | DRD4 (0.54) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL1388551 | 0.68 | DRD4 (0.70) | DRD2DRD4DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665833-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-09 | — | — | EP | claimed |