Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10961510 | 0.74 | MAOB (0.40) | MAOBMAOAKCNN4HSD11B1SLC6A3 | |
| SCHEMBL2173336 | 0.64 | SLC6A3 (0.42) | MAOBMAOAHSD11B1SLC6A3SLC6A2 | |
| SCHEMBL2175183 | 0.61 | SLC6A3 (0.40) | MAOBMAOAHSD11B1SLC6A3SLC6A2 | |
| SCHEMBL13221434 | 0.61 | MAOB (0.50) | MAOBMAOAHSD11B1SLC6A3SLC6A2 | |
| Alcohol SCHEMBL28041790 | 0.61 | ACHE (0.53) | ACHE | |
| SCHEMBL12457116 | 0.60 | SLC6A3 (0.52) | MAOBMAOAHSD11B1SLC6A3SLC6A2 | |
| SCHEMBL25502573 | 0.60 | MAOB (0.43) | MAOBMAOAHSD11B1SLC6A3SLC6A2 | |
| SCHEMBL19262183 | 0.59 | LMNA (0.41) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL19809428 | 0.59 | CHRM2 (0.37) | — | |
| Ethylamine SCHEMBL27972784 | 0.59 | LOXL2 (0.58) | MAOBMAOASLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354539-B1 | Antiinflammatory carbinoloimidazoles | DU PONT MERCK PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0354539-A2 | Antiinflammatory carbinoloimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-02-14 | — | — | EP | disclosed |
| US-4859693-A | Antiinflammatory carbinoloimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-22 | — | — | US | disclosed |