Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9436686 | 0.85 | HDAC8 (0.45) | HDAC6HDAC8HDAC1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL8817084 | 0.85 | KDM4E (0.43) | POLBNPC1PRSS1KDM4EALDH1A1 | |
| SCHEMBL9436680 | 0.84 | HDAC6 (0.52) | HDAC6HDAC8HDAC1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL8814721 | 0.84 | PRSS1 (0.41) | PRSS1KDM4EALDH1A1LMNATSHR | |
| SCHEMBL9194819 | 0.84 | PTGER4 (0.47) | POLBNPC1PRSS1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9192096 | 0.83 | PTGER4 (0.46) | POLBNPC1PRSS1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8816481 | 0.82 | HCAR3 (0.38) | F10KMT2ANPC1PRSS1KDM4E | |
| SCHEMBL9197022 | 0.82 | SLC9A1 (0.50) | HDAC6HDAC8HDAC1 | |
| SCHEMBL8743856 | 0.81 | MAPT (0.42) | F10PRSS1KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8896876 | 0.81 | SCN2A (0.40) | HDAC1F10SCN5ASCN2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416499-B1 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |