Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197022 | 0.85 | SLC9A1 (0.50) | HDAC6HDAC8HDAC1 | |
| SCHEMBL9197014 | 0.84 | HDAC6 (0.50) | HDAC6HDAC8HDAC1ALDH1A1LMNA | |
| SCHEMBL9196904 | 0.84 | L3MBTL1 (0.50) | HDAC6HDAC8HDAC1ALDH1A1TSHR | |
| SCHEMBL9436753 | 0.81 | PTGER4 (0.55) | ALDH1A1LMNATSHRBLMHSD17B10 | |
| SCHEMBL11180243 | 0.75 | TDP1 (0.73) | HDAC6HDAC8HDAC1ALDH1A1TSHR | |
| SCHEMBL6801960 | 0.74 | NPSR1 (0.43) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL6801964 | 0.74 | NPSR1 (0.43) | ALDH1A1MAPTKDM4EHPGDNPSR1 | |
| SCHEMBL13805751 | 0.73 | HCAR3 (0.51) | ALDH1A1HSD17B10NPC1MAPTKMT2A | |
| SCHEMBL22499500 | 0.73 | KDM4E (0.63) | ALDH1A1LMNATSHRBLMHSD17B10 | |
| SCHEMBL1287375 | 0.72 | TDP1 (0.62) | HDAC6HDAC8HDAC1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |