Acetic Acid

Acetic Acid

SCHEMBL9436686

CC(=O)O.CS(=O)(=O)c1cc(C(=O)NC(=N)N)ccc1NCc1ccccc1

nearest known ligand 0.45

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 6/20 0.45
HDAC1 Q13547 4/20 0.45
HDAC6 Q9UBN7 4/20 0.45
ALDH1A1 P00352 4/20 0.42
GAA P10253 2/20 0.42
HSD17B10 Q99714 1/20 0.42
CA12 O43570 5/20 0.40
CA1 P00915 5/20 0.40
CA2 P00918 5/20 0.40
CA3 P07451 5/20 0.40
CA6 P23280 5/20 0.40
CA7 P43166 5/20 0.40
CA13 Q8N1Q1 5/20 0.40
CA14 Q9ULX7 5/20 0.40
CA5A P35218 4/20 0.40
CA9 Q16790 4/20 0.40
CA5B Q9Y2D0 4/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
KDM4E B2RXH2 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8815198 0.86 HDAC8 (0.47) HDAC8HDAC1HDAC6CA1CA2
SCHEMBL9197014 0.85 HDAC6 (0.50) HDAC8HDAC1HDAC6ALDH1A1HSD17B10
SCHEMBL8743856 0.83 MAPT (0.42) ALDH1A1GAAKDM4ELMNAKLKB1
Hydrochloric Acid SCHEMBL8743788 0.82 MAPT (0.41) ALDH1A1GAAKDM4ELMNAKLKB1
SCHEMBL9196904 0.81 L3MBTL1 (0.50) HDAC8HDAC1HDAC6ALDH1A1GAA
Hydrochloric Acid SCHEMBL8816481 0.80 HCAR3 (0.38) ALDH1A1HSD17B10CA12CA1CA2
SCHEMBL8983612 0.79 SLC9A1 (0.38) CA1CA2
SCHEMBL8983574 0.79 SLC9A1 (0.38) CA1CA2
SCHEMBL8983581 0.79 SLC9A1 (0.38) CA1CA2
Hydrochloric Acid SCHEMBL9197038 0.79 SLC9A1 (0.38) ALDH1A1GAAHSD17B10CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292755-A USPA benzolyguanidines HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-08 US disclosed
US-5091394-A BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed