Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.43 |
| ▸ | RARG | P13631 | 11/20 | 0.43 |
| ▸ | RARA | P10276 | 10/20 | 0.43 |
| ▸ | RXRA | P19793 | 8/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265000 | 0.81 | RXRA (0.69) | RARBRARGRARARXRARXRB | |
| SCHEMBL6243526 | 0.80 | HTT (0.46) | RARBRARGRARA | |
| SCHEMBL7784294 | 0.80 | RARB (0.45) | RARBRARGRARARXRARXRB | |
| SCHEMBL9186987 | 0.79 | RXRA (0.52) | RARBRARGRARARXRARXRB | |
| SCHEMBL9143255 | 0.78 | RARB (0.57) | RARBRARGRARARXRARXRB | |
| SCHEMBL10437692 | 0.74 | RARB (0.78) | RARBRARGRARARXRARXRB | |
| SCHEMBL9189346 | 0.74 | RARB (0.60) | RARBRARGRARARXRARXRB | |
| SCHEMBL9186679 | 0.74 | RARA (0.61) | RARBRARGRARARXRACYP3A4 | |
| SCHEMBL9523050 | 0.73 | RXRA (0.50) | RARBRARGRARARXRARXRB | |
| SCHEMBL2939205 | 0.72 | RARB (0.45) | RARBRARGRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350846-B1 | Condensed heterocyclic compounds and their use in therapy | HOFFMANN LA ROCHE (CH) | 1995-10-11 | — | — | EP | disclosed |
| EP-0350846-A2 | Condensed heterocyclic compounds and their use in therapy | F. HOFFMANN-LA ROCHE AG (CH) | 1990-01-17 | — | — | EP | disclosed |