Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMTK3 | Q96Q04 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9287557 | 0.92 | HTR6 (0.35) | POLBALDH1A1 | |
| SCHEMBL7445975 | 0.85 | POLB (0.38) | POLBSMN1; SMN2KMT2AGBA1CYP2C9 | |
| SCHEMBL6176220 | 0.81 | VKORC1 (0.37) | KMT2ACYP2C9ALDH1A1LMNAHTT | |
| SCHEMBL27333913 | 0.81 | VKORC1 (0.36) | KMT2ACYP2C9ALDH1A1CYP3A4LMNA | |
| SCHEMBL7442256 | 0.80 | POLB (0.40) | POLBGBA1CYP2C9ALDH1A1LMNA | |
| SCHEMBL6174524 | 0.78 | CYP2C9 (0.36) | CYP2C9 | |
| SCHEMBL6177695 | 0.78 | CYP2C9 (0.38) | KMT2ACYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL7445970 | 0.78 | ALDH1A1 (0.37) | POLBSMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL7445966 | 0.77 | TACR1 (0.34) | POLBKMT2ACYP2C9ALDH1A1 | |
| SCHEMBL7441063 | 0.77 | KCNK3 (0.36) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | claimed |