Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207677 | 0.86 | PTGS2 (0.50) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL9203418 | 0.86 | PTGS2 (0.53) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL9214200 | 0.84 | PTGS2 (0.46) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL9204622 | 0.83 | PTGS2 (0.45) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL27342072 | 0.83 | ALOX5 (0.61) | PTGS2ALOX5PTGS1 | |
| SCHEMBL9210122 | 0.82 | PTGS2 (0.44) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL9206528 | 0.81 | RXRA (0.40) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL9209318 | 0.81 | PTGS2 (0.43) | RXRANR1H2NR1H3PTGS2ALOX5 | |
| SCHEMBL8953954 | 0.80 | RXRA (0.82) | RXRANR1H2NR1H3PTGS2PTGS1 | |
| SCHEMBL7867777 | 0.80 | PTGS2 (0.54) | PTGS2ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |