Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204779 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL9203970 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL9207677 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1ALOX5RXRANR1H2 | |
| SCHEMBL9199704 | 0.86 | RXRA (0.55) | PTGS2PTGS1ALOX5RXRANR1H2 | |
| SCHEMBL9214200 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1ALOX5RXRANR1H2 | |
| SCHEMBL9204622 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1ALOX5RXRANR1H2 | |
| SCHEMBL27342072 | 0.83 | ALOX5 (0.61) | PTGS2PTGS1ALOX5CYP2C9 | |
| SCHEMBL9210122 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1ALOX5RXRANR1H2 | |
| SCHEMBL9208027 | 0.81 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL9201549 | 0.81 | PTGS2 (0.78) | PTGS2PTGS1ALOX5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |