Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672467 | 0.84 | SIGMAR1 (0.42) | SIGMAR1CYP2D6KIF11CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL3672966 | 0.84 | SIGMAR1 (0.49) | SIGMAR1CYP2D6KIF11 | |
| Hydrochloric Acid SCHEMBL3670608 | 0.78 | SIGMAR1 (0.49) | SIGMAR1CYP2D6 | |
| SCHEMBL3594198 | 0.78 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9673637 | 0.78 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9673634 | 0.78 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7833286 | 0.78 | CFB (0.39) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7965310 | 0.76 | CHRNB2 (0.46) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18824255 | 0.75 | MAPK1 (0.46) | SIGMAR1CYP2D6P2RX7KIF11CHRNB2 | |
| SCHEMBL10409487 | 0.75 | SIGMAR1 (0.39) | SIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445811-B1 | Nitrogen-containing heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-14 | — | — | EP | disclosed |
| US-5304565-A | Angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| US-5284661-A | 4-Oxo-7-(biphenyl-4-yl)thieno(2,3-b)pyridines as antagonist of angiotensin II; hypertensive agents, cardiovascular disorders and strokes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0445811-A2 | Nitrogen-containing heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-09-11 | — | — | EP | disclosed |
| EP-0443568-A1 | Fused thiophene derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |