Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673634 | 0.80 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9673637 | 0.80 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3594198 | 0.80 | CHRNB2 (0.53) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22473389 | 0.78 | RIPK1 (0.43) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| Hydrochloric Acid SCHEMBL7965310 | 0.78 | CHRNB2 (0.46) | CFBSIGMAR1CYP2D6CHRNB2CHRNB4 | |
| SCHEMBL9199829 | 0.78 | SIGMAR1 (0.40) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5672467 | 0.76 | SIGMAR1 (0.42) | SIGMAR1CYP2D6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL23491401 | 0.75 | RIPK1 (0.40) | CFBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10409487 | 0.73 | SIGMAR1 (0.39) | SIGMAR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL3672966 | 0.73 | SIGMAR1 (0.49) | SIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140876-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035891-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |