Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.75 |
| ▸ | HTR1D | P28221 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | HTR1E | P28566 | 2/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
| ▸ | HTR5A | P47898 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952945 | 0.84 | HTR6 (0.62) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL31543684 | 0.81 | MTNR1A (0.75) | ALDH1A1KDM4EHSD17B10TSHRHPGD | |
| SCHEMBL11374190 | 0.81 | ALDH1A1 (0.78) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL8691195 | 0.81 | HTR6 (0.71) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL15902322 | 0.80 | AHR (0.59) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL26227993 | 0.79 | HSD17B10 (0.56) | HTR6HTR1DHTR2AALDH1A1KDM4E | |
| SCHEMBL29389149 | 0.79 | HTR6 (1.00) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL2537573 | 0.79 | HTR6 (1.00) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL9209940 | 0.78 | MEN1 (0.54) | HTR6HTR1DHTR1AHTR1EHTR7 | |
| SCHEMBL22722590 | 0.78 | HTR6 (0.59) | HTR6HTR1DHTR1AHTR1EHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |