Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.71 |
| ▸ | HTR1D | P28221 | 4/20 | 0.71 |
| ▸ | HTR1A | P08908 | 3/20 | 0.71 |
| ▸ | HTR7 | P34969 | 3/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | HTR1E | P28566 | 2/20 | 0.71 |
| ▸ | HTR5A | P47898 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29389149 | 0.83 | HTR6 (1.00) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL2537573 | 0.83 | HTR6 (1.00) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL8802574 | 0.83 | MTNR1A (0.67) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL4244966 | 0.82 | HTR1D (1.00) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL8229569 | 0.81 | HTR6 (0.72) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL8946961 | 0.81 | HTR6 (0.72) | HTR6HTR1DHTR1AHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL7433474 | 0.81 | HTR1D (0.97) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL9200463 | 0.81 | HTR6 (0.75) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL22722590 | 0.80 | HTR6 (0.59) | HTR6HTR1DHTR1AHTR7HTR2A | |
| SCHEMBL4656354 | 0.79 | SIRT1 (0.58) | HTR6HTR1DHTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047386-C | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1999-12-15 | — | — | CN | disclosed |
| US-5763471-A | TREATS PSYCHIATARIC AND BRAIN DISORDERS | CEMAF (FR) | 1998-06-09 | — | — | US | disclosed |
| CN-1148855-A | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1997-04-30 | — | — | CN | disclosed |