SCHEMBL9200511

SCHEMBL9200511

CC1=C(c2ccccc2SSc2ccccc2C2=C(C)C(=O)NC2=O)C(=O)NC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK10 O94804 12/20 0.43
SLK Q9H2G2 12/20 0.43
GSK3B P49841 6/20 0.43
CASP3 P42574 1/20 0.38
CASP2 P42575 1/20 0.38
CASP7 P55210 1/20 0.38
CASP6 P55212 1/20 0.38
CASP8 Q14790 1/20 0.38
CLK2 P49760 1/20 0.38
GSK3A P49840 1/20 0.38
PTGS2 P35354 1/20 0.38
CCNE2 O96020 2/20 0.36
CDK4 P11802 2/20 0.36
CCND1 P24385 2/20 0.36
CCNE1 P24864 2/20 0.36
CDK2 P24941 2/20 0.36
PRKD3 O94806 1/20 0.35
CCNB2 O95067 1/20 0.35
ABL1 P00519 1/20 0.35
PRKCG P05129 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9204436 0.89 STK10 (0.43) STK10SLKGSK3BCASP3CASP2
SCHEMBL9208013 0.85 STK10 (0.41) STK10SLKGSK3BCASP3CASP2
SCHEMBL19583334 0.85 GSK3B (0.54) STK10SLKGSK3BCASP3CASP2
SCHEMBL9206390 0.83 STK10 (0.46) STK10SLKGSK3BCASP3CASP2
SCHEMBL3675474 0.79 GSK3B (0.48) STK10SLKGSK3BCASP3CASP2
SCHEMBL9203366 0.74 CDK4 (0.46) STK10SLKGSK3BPTGS2CDK4
SCHEMBL3671511 0.74 GSK3B (0.66) STK10SLKGSK3BCLK2GSK3A
SCHEMBL8890003 0.72 MYC (0.49) GSK3BGSK3A
SCHEMBL9064980 0.71 GSK3B (0.39) STK10SLKGSK3BCASP3CASP2
SCHEMBL94149 0.71 GSK3B (0.58) GSK3BPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115477605-A Efficient synthesis method and application of bis- (2-citraconimidophenyl) dithio 江苏锐巴新材料科技有限公司 2022-12-16 CN claimed
CN-115477605-A Efficient synthesis method and application of bis- (2-citraconimidophenyl) dithio 江苏锐巴新材料科技有限公司 2022-12-16 CN disclosed
CN-115477605-A Efficient synthesis method and application of bis- (2-citraconimidophenyl) dithio 江苏锐巴新材料科技有限公司 2022-12-16 CN disclosed
EP-0556203-B1 (POLY)SULFIDE CONTAINING POLYCITRACONIMIDES AND POLYITACONIMIDES AKZO NOBEL NV (NL) 1995-10-11 EP disclosed
US-5405918-A Accelerators for sulfur-vulcanization of rubber; tires AKZO NOBEL N.V. (NL) 1995-04-11 US disclosed
EP-0640114-A1 SULFUR-VULCANIZED RUBBER COMPOSITION Akzo Nobel N.V. (NL) 1995-03-01 EP disclosed
WO-1993023467-A1 SULFUR-VULCANIZED RUBBER COMPOSITION AKZO NOBEL N.V. (NL) 1993-11-25 WO disclosed
EP-0556203-A1 (POLY)SULFIDE CONTAINING POLYCITRACONIMIDES AND POLYITACONIMIDES. AKZO NV (NL) 1993-08-25 EP disclosed
WO-1992007828-A1 (POLY)SULFIDE CONTAINING POLYCITRACONIMIDES AND POLYITACONIMIDES AKZO N.V. (NL) 1992-05-14 WO disclosed