SCHEMBL8890003

SCHEMBL8890003

CC1=C(c2ccccc2C(=O)O)C(=O)NC1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 1/20 0.49
LIG1 P18858 1/20 0.46
GSK3B P49841 3/20 0.45
GSK3A P49840 1/20 0.45
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX12 P18054 1/20 0.44
FABP3 P05413 1/20 0.42
FABP4 P15090 1/20 0.42
FABP5 Q01469 1/20 0.42
ALDH1A1 P00352 5/20 0.42
KDM4E B2RXH2 2/20 0.42
ALOX15 P16050 1/20 0.42
USP2 O75604 1/20 0.42
TSHR P16473 1/20 0.42
GAA P10253 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9064980 0.82 GSK3B (0.39) GSK3BGSK3AALDH1A1KDM4EGAA
SCHEMBL19583334 0.82 GSK3B (0.54) GSK3BGSK3A
SCHEMBL11527833 0.80 GSK3B (0.48) MYCLIG1GSK3BGSK3ACYP3A4
SCHEMBL3675474 0.77 GSK3B (0.48) GSK3BMEN1KMT2APOLB
Phthalic Acid SCHEMBL28249734 0.76 GSK3B (0.65) MYCLIG1GSK3BCYP3A4CYP2C9
Phthalic Acid SCHEMBL28572075 0.74 GSK3B (0.62) MYCLIG1GSK3BALDH1A1KDM4E
SCHEMBL9204436 0.72 STK10 (0.43) GSK3BGSK3A
SCHEMBL9200511 0.72 STK10 (0.43) GSK3BGSK3A
SCHEMBL94149 0.72 GSK3B (0.58) GSK3B
SCHEMBL10349769 0.71 ALDH1A1 (0.54) MYCLIG1GSK3BCYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0336856-B1 WITH MALEIMIDE GROUPS FUNCTIONALIZED AROMATIC POLYAMIDEIMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR PREPARING CROSS-LINKED POLYMERS CIBA-GEIGY AG (CH) 1993-03-03 EP claimed
US-4927900-A Aromatic polyamidoimides having maleimido end groups RHONE-POULENC CHIMIE (FR) 1990-05-22 US claimed
WO-1997003962-A1 IMIDO PERESTERS AS INITIATORS OF POLYMERIZATION PROCESSES AKZO NOBEL N.V. (NL) 1997-02-06 WO disclosed
US-5470920-A Impregnating solutions based on at least one reactive thermoplastic poly (imide-amide) oligomer and a coreactant, which can be used especially for the production of preimpregnated intermediate articles CIBA-GEIGY CORPORATION (US) 1995-11-28 US disclosed
US-4927900-A Aromatic polyamidoimides having maleimido end groups RHONE-POULENC CHIMIE (FR) 1990-05-22 US disclosed