Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205175 | 0.94 | LTB4R2 (0.48) | LTB4R2CYP2C9FOLH1KDM4ECYP1A2 | |
| SCHEMBL8670621 | 0.86 | LTB4R2 (0.51) | LTB4R2PPARAPPARGPPARDBDKRB1 | |
| SCHEMBL9204918 | 0.85 | LTB4R2 (0.40) | LTB4R2CYP2C9PPARAPPARGPPARD | |
| SCHEMBL9280307 | 0.83 | LTB4R2 (0.46) | LTB4R2CYP2C9FOLH1KDM4ECYP1A2 | |
| SCHEMBL8671881 | 0.80 | LTB4R2 (0.57) | LTB4R2BDKRB1 | |
| SCHEMBL9195365 | 0.76 | LTB4R2 (0.39) | LTB4R2KDM4ECYP1A2CYP2C19PPARA | |
| SCHEMBL9024939 | 0.76 | LTB4R2 (0.58) | LTB4R2 | |
| SCHEMBL534889 | 0.74 | KDM4E (0.50) | LTB4R2CYP2C9FOLH1KDM4ECYP1A2 | |
| SCHEMBL10512148 | 0.74 | LOXL2 (0.51) | CYP2C9FOLH1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL9448762 | 0.74 | MMP8 (0.41) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680480-A1 | PYRIMIDINONE DERIVATIVES FUSED TO NITROGEN HETEROCYCLES HAVING A II ANTAGONISTIC ACTIVITY. | LUSO FARMACO INST (IT) | 1995-11-08 | — | — | EP | disclosed |
| EP-0641329-A1 | COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1995-03-08 | — | — | EP | disclosed |