Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199522 | 0.82 | SLC6A3 (0.40) | NPC1SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL9200324 | 0.80 | NPC1 (0.38) | NPC1SMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL9198960 | 0.78 | TDP1 (0.37) | NPC1ALDH1A1POLBPRKDCPIK3CD | |
| SCHEMBL9200491 | 0.78 | APAF1 (0.39) | NPC1SMN1; SMN2POLBPRKDCPIK3CD | |
| SCHEMBL9196278 | 0.77 | APAF1 (0.39) | NPC1SMN1; SMN2RAB9APOLBPRKDC | |
| SCHEMBL9204759 | 0.76 | SLC6A3 (0.40) | NPC1SMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL9201037 | 0.75 | RXFP1 (0.42) | NPC1SMN1; SMN2MAPTRAB9APOLB | |
| SCHEMBL9196127 | 0.74 | NPC1 (0.51) | NPC1SMN1; SMN2MAPTPOLBHTT | |
| SCHEMBL9197464 | 0.73 | NPC1 (0.35) | NPC1SMN1; SMN2POLBHTTCHRM5 | |
| SCHEMBL9200379 | 0.73 | NPC1 (0.35) | NPC1SMN1; SMN2MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575425-B1 | USE OF OXAZOLO- 2,3-a]ISOINDOLE AND IMIDAZO 2,1-a]ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS, AND NEW OXAZOLO 2,3-a]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-10-11 | — | — | EP | disclosed |
| EP-0575425-A1 | USE OF OXAZOLO- 2,3-a]ISOINDOLE AND IMIDAZO 2,1-a]ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS, AND NEW OXAZOLO 2,3-a]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992016207-A1 | USE OF OXAZOLO-[2,3-a]ISOINDOLE AND IMIDAZO[2,1-a]ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS, AND NEW OXAZOLO[2,3-a]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |