Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2900297 | 0.82 | LMNA (0.60) | LMNATP53POLBALDH1A1GAA | |
| SCHEMBL4340762 | 0.82 | TSHR (0.59) | LMNATP53POLBGAAKMT2A | |
| SCHEMBL1855445 | 0.76 | LMNA (0.62) | LMNATP53POLBALDH1A1GAA | |
| SCHEMBL9143246 | 0.76 | ALDH1A1 (0.66) | ALDH1A1KMT2ATSHRRAB9AHPGD | |
| SCHEMBL3876644 | 0.75 | KMT2A (0.62) | LMNATP53POLBALDH1A1GAA | |
| SCHEMBL9142407 | 0.72 | KDM4E (0.63) | POLBALDH1A1KMT2ATSHRRAB9A | |
| SCHEMBL7030084 | 0.72 | LMNA (0.42) | LMNAPOLBALDH1A1GAAKMT2A | |
| SCHEMBL14240450 | 0.72 | RARB (0.50) | LMNAPOLBALDH1A1GAAKMT2A | |
| SCHEMBL5567525 | 0.72 | NPC1 (0.53) | POLBRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9200174 | 0.72 | RXRA (0.50) | ACACBCA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350846-B1 | Condensed heterocyclic compounds and their use in therapy | HOFFMANN LA ROCHE (CH) | 1995-10-11 | — | — | EP | disclosed |
| EP-0350846-A2 | Condensed heterocyclic compounds and their use in therapy | F. HOFFMANN-LA ROCHE AG (CH) | 1990-01-17 | — | — | EP | disclosed |