Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.38 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301450 | 1.00 | APEX1 (0.58) | APEX1BLMGSK3AGSK3BELANE | |
| SCHEMBL9203370 | 1.00 | APEX1 (0.58) | APEX1BLMGSK3AGSK3BELANE | |
| SCHEMBL11523742 | 0.84 | APEX1 (0.47) | APEX1BLMKMT2AALDH1A1ALOX15 | |
| SCHEMBL21389170 | 0.83 | APEX1 (0.62) | APEX1BLMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL21389109 | 0.83 | APEX1 (0.62) | APEX1BLMKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9301677 | 0.81 | GSK3A (0.41) | APEX1BLMGSK3AGSK3BELANE | |
| SCHEMBL10681074 | 0.81 | ALDH1A1 (0.43) | GSK3AGSK3BELANEALDH1A1PIN1 | |
| SCHEMBL10626979 | 0.80 | APEX1 (0.54) | APEX1BLMTDP1RAB9AALDH1A1 | |
| SCHEMBL563088 | 0.80 | GSK3A (0.41) | APEX1BLMGSK3AGSK3BELANE | |
| SCHEMBL563087 | 0.80 | GSK3A (0.41) | APEX1BLMGSK3AGSK3BELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0408524-B1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | SIGMA TAU IND FARMACEUTI (IT) | 1995-11-08 | — | — | EP | disclosed |
| US-5061725-A | COGNITION ACTIVATORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1991-10-29 | — | — | US | disclosed |
| EP-0408524-A1 | (Pyrrolidin-2-on-l-yl) acetamides as enhancers of learning and memory and pharmaceutical compositions comprising same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-01-16 | — | — | EP | disclosed |