Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | EEF2K | O00418 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201688 | 0.85 | PHGDH (0.55) | KDM4EALDH1A1SMN1; SMN2EEF2K | |
| SCHEMBL4602793 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1HTT | |
| SCHEMBL7130439 | 0.81 | LMNA (0.72) | KDM4EALDH1A1HTTTSHRSMN1; SMN2 | |
| SCHEMBL7474168 | 0.81 | KDM4E (0.76) | KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL27911661 | 0.80 | SIGMAR1 (0.58) | — | |
| SCHEMBL4605773 | 0.79 | LMNA (0.52) | HTTSMN1; SMN2 | |
| SCHEMBL224090 | 0.78 | MEN1 (0.70) | KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4601925 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL642396 | 0.77 | KDM4E (0.64) | KDM4EHTTSMN1; SMN2 | |
| SCHEMBL30064781 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353821-B1 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5015740-A | Psychological disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-05-14 | — | — | US | disclosed |
| US-4957916-A | DISORDERS CONNECTED WITH DOPAMINE AND/OR SEROTONIN RELEASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-09-18 | — | — | US | disclosed |
| EP-0353821-A2 | Antipsychotic 3-piperazinyl-benzazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-02-07 | — | — | EP | disclosed |