Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200880 | 0.90 | PTGS2 (0.63) | PTGS2CHRNA7ALOX5CYP2C9PTGS1 | |
| SCHEMBL9199556 | 0.89 | AOC3 (0.65) | PTGS2CHRNA7AOC3CYP2C9PTGS1 | |
| SCHEMBL9209551 | 0.89 | ALOX5 (0.60) | PTGS2CHRNA7ALOX5 | |
| SCHEMBL9207362 | 0.89 | RPA1 (0.62) | PTGS2ALOX5AOC3SMN1; SMN2 | |
| SCHEMBL8925566 | 0.88 | CHRNA7 (0.57) | PTGS2CHRNA7ALOX5AOC3CYP2C9 | |
| SCHEMBL8925594 | 0.88 | RARG (0.60) | PTGS2CHRNA7ALOX5AOC3SMN1; SMN2 | |
| SCHEMBL9208261 | 0.88 | CHRNA7 (0.51) | PTGS2CHRNA7ALOX5AOC3CYP2C9 | |
| SCHEMBL9199063 | 0.87 | CHRNA7 (0.66) | PTGS2CHRNA7PTGS1SMN1; SMN2 | |
| SCHEMBL9744795 | 0.87 | PTGS2 (0.55) | PTGS2CHRNA7PTGS1SMN1; SMN2 | |
| SCHEMBL9210999 | 0.87 | PTGS2 (0.55) | PTGS2CHRNA7ALOX5AOC3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |