Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209551 | 0.89 | ALOX5 (0.60) | CHRNA7ALOX5PTGS2 | |
| SCHEMBL9208255 | 0.89 | RPA1 (0.57) | AOC3ALOX5PTGS2SMN1; SMN2 | |
| SCHEMBL9200880 | 0.88 | PTGS2 (0.63) | CHRNA7ALOX5PTGS2SMN1; SMN2CYP2C9 | |
| SCHEMBL9204576 | 0.88 | PTGS2 (0.59) | CHRNA7AOC3ALOX5PTGS2SMN1; SMN2 | |
| SCHEMBL9199556 | 0.87 | AOC3 (0.65) | CHRNA7AOC3PTGS2CYP2C9 | |
| SCHEMBL8925566 | 0.86 | CHRNA7 (0.57) | CHRNA7AOC3ALOX5PTGS2SMN1; SMN2 | |
| SCHEMBL8925594 | 0.86 | RARG (0.60) | CHRNA7AOC3ALOX5PTGS2SMN1; SMN2 | |
| SCHEMBL9744795 | 0.85 | PTGS2 (0.55) | CHRNA7PTGS2SMN1; SMN2 | |
| SCHEMBL9210999 | 0.85 | PTGS2 (0.55) | CHRNA7AOC3ALOX5PTGS2SMN1; SMN2 | |
| SCHEMBL9199063 | 0.85 | CHRNA7 (0.66) | CHRNA7PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |