SCHEMBL9205296

SCHEMBL9205296

COc1ccc2c(Cl)onc2c1Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.38
TSHR P16473 5/20 0.35
NPC1 O15118 4/20 0.35
RAB9A P51151 3/20 0.35
HSD17B10 Q99714 2/20 0.35
MAPK1 P28482 1/20 0.35
CASP1 P29466 1/20 0.35
MAPT P10636 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 1/20 0.34
CYP19A1 P11511 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
STAT3 P40763 1/20 0.34
HTR3A P46098 2/20 0.33
CHUK O15111 1/20 0.33
PRKD3 O94806 1/20 0.33
PRKCG P05129 1/20 0.33
PRKCB P05771 1/20 0.33
PRKCA P17252 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6954025 0.73 HTR3A (0.36) ALDH1A1TSHRNPC1RAB9AHSD17B10
SCHEMBL17142264 0.70 ALDH1A1 (0.43) ALDH1A1MAPTSMN1; SMN2POLBKDM4E
SCHEMBL288555 0.69 CYP19A1 (0.42) ALDH1A1NPC1MAPTCYP19A1CYP11B1
SCHEMBL17086891 0.69 CYP19A1 (0.45) ALDH1A1MAPTCYP19A1CYP11B1CYP11B2
SCHEMBL12646517 0.68 EDNRA (0.41) ALDH1A1TSHRHSD17B10MAPTCYP19A1
SCHEMBL38659237 0.67 CYP19A1 (0.44) ALDH1A1MAPTCYP19A1CYP11B1CYP11B2
SCHEMBL288743 0.67 TSHR (0.42) TSHRHSD17B10LMNACYP1A2CYP3A4
SCHEMBL10398173 0.66 CA2 (0.47) ALDH1A1TSHRRAB9AMAPK1MAPT
SCHEMBL29800758 0.66 CA2 (0.47) ALDH1A1TSHRRAB9AMAPK1MAPT
SCHEMBL2386245 0.64 LMNA (0.42) MAPK1MAPTPOLBCYP19A1CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0669920-A4 SUBSTITUTED 3-(AMINOALKYLAMINO)-1,2-BENZISOXAZOLES AND RELATED COMPOUNDS. HOECHST ROUSSEL PHARMA (US) 1995-10-25 EP disclosed
EP-0669920-A1 SUBSTITUTED 3-(AMINOALKYLAMINO)-1,2-BENZISOXAZOLES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, Inc. (US) 1995-09-06 EP disclosed