Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206950 | 1.00 | LMNA (0.50) | LMNATP53CCKBRF10F2 | |
| SCHEMBL9206962 | 1.00 | LMNA (0.50) | LMNATP53CCKBRF10F2 | |
| SCHEMBL9200577 | 0.89 | UBE2M (0.46) | LMNATP53CCKBRF10 | |
| SCHEMBL9200559 | 0.89 | UBE2M (0.46) | LMNATP53CCKBRF10 | |
| SCHEMBL9200567 | 0.89 | UBE2M (0.46) | LMNATP53CCKBRF10 | |
| SCHEMBL9205891 | 0.86 | CCKBR (0.54) | CCKBRDRD4 | |
| SCHEMBL9205881 | 0.86 | CCKBR (0.54) | CCKBRDRD4 | |
| SCHEMBL9205875 | 0.86 | CCKBR (0.54) | CCKBRDRD4 | |
| SCHEMBL9205584 | 0.85 | CCKBR (0.58) | LMNATP53CCKBRF10SMN1; SMN2 | |
| SCHEMBL9202339 | 0.85 | CCKBR (0.58) | LMNATP53CCKBRF10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561941-B1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | SEARLE & CO (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5314886-A | N-substituted lactams useful as cholecystokinin antagonists | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | disclosed |
| US-5202344-A | Disorders of the gastrointestinal, central nervous system and appetite regulatory systems | G. D. SEARLE & CO. (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1992010476-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-06-25 | — | — | WO | disclosed |