Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 6/20 | 0.35 |
| ▸ | NOS2 | P35228 | 6/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131114 | 0.80 | NOS2 (0.37) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL22350973 | 0.80 | CCR1 (0.48) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL27227418 | 0.77 | ALDH1A1 (0.37) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL29952613 | 0.77 | ALDH1A1 (0.46) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL1863142 | 0.77 | ALDH1A1 (0.46) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL249689 | 0.77 | NOS2 (0.54) | CCR1CCR5CCR8NOS3NOS2 | |
| SCHEMBL17984974 | 0.77 | NOS2 (0.54) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL5423975 | 0.76 | CCR1 (0.48) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL17984975 | 0.72 | CCR1 (0.45) | CCR1CCR5CCR8TRIM24TRIM33 | |
| SCHEMBL29955522 | 0.72 | CCR1 (0.41) | CCR1CCR5CCR8TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404797-B1 | 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | SEARLE & CO (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0404797-A4 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL)IMIDAZO 4,5-C)PYRIDINES AS PAF ANTAGONISTS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0404797-A1 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO 4,5-c]PYRIDINES AS PAF ANTAGONISTS. | SEARLE & CO (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4962106-A | Treating platelet activating factor mediated disorders | G. D. SEARLE & CO. (US) | 1990-10-09 | — | — | US | disclosed |
| WO-1989008653-A1 | 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1989-09-21 | — | — | WO | disclosed |
| US-4804658-A | PLATELET-ACTIVATING FACTOR ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0260613-A2 | Imidazopyridine derivatives, their preparation and their use as PAF-antagonists | G.D. Searle & Co. (US) | 1988-03-23 | — | — | EP | disclosed |