SCHEMBL920728

SCHEMBL920728

Nc1ncc(F)cc1C(=O)NCc1ccc(Oc2ccccc2)s1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 3/20 0.44
MAPK8 P45983 2/20 0.39
MET P08581 4/20 0.38
MAPK14 Q16539 1/20 0.37
MAPK1 P28482 3/20 0.37
MAPT P10636 1/20 0.36
PTGER2 P43116 1/20 0.36
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1680398 0.90 MAPK8 (0.40) MAPK8MAPK14CA2CA4
SCHEMBL1680774 0.88 PTGER4 (0.42) PTGER4MAPK8METMAPK14PTGER2
SCHEMBL1680833 0.88 PTGER4 (0.42) PTGER4MAPK8MAPK14CA2CA4
SCHEMBL1680258 0.88 MAPK8 (0.39) MAPK8METMAPK14CA2CA4
SCHEMBL1680626 0.84 FFAR1 (0.42) MAPK8MAPTCA2CA4
SCHEMBL1681128 0.83 PIK3CD (0.44) MAPK8MAPK14CA2CA4
SCHEMBL1680415 0.83 MAPK8 (0.52) MAPK8MAPK14
SCHEMBL920768 0.82 PTGER4 (0.61) PTGER4MAPK8MAPK14MAPTPTGER2
SCHEMBL921262 0.81 MAPK8 (0.38) MAPK8MAPK14MAPK1MAPTCA2
SCHEMBL1680602 0.80 KMT2A (0.44) MAPK8MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 PTGER4 3181/4885MAPK8 2313/4885MET 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.