Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302824 | 0.70 | PDE4A (0.38) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL7676771 | 0.68 | ALDH1A1 (0.36) | ALDH1A1TSHRALOX15LMNAMEN1 | |
| SCHEMBL11716332 | 0.66 | ADORA3 (0.44) | ALDH1A1TSHRMEN1KMT2ACYP2C9 | |
| SCHEMBL11725911 | 0.66 | ADORA3 (0.44) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL25360981 | 0.65 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNAKMT2AMAPT | |
| SCHEMBL8339196 | 0.65 | MAPT (0.41) | ALDH1A1TSHRALOX15LMNAMEN1 | |
| SCHEMBL23898540 | 0.65 | ALDH1A1 (0.42) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL29001497 | 0.64 | PDE3B (0.39) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL994763 | 0.62 | ALDH1A1 (0.54) | ALDH1A1TSHRALOX15LMNAKMT2A | |
| SCHEMBL5539986 | 0.61 | ALDH1A1 (0.47) | ALDH1A1TSHRALOX15LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664803-A1 | N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008989-A1 | N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1994-04-28 | — | — | WO | disclosed |