Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CALML3 | P27482 | 4/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 12/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845306 | 1.00 | MAOA (0.51) | MAOAMAOBSIGMAR1CALML3GRM2 | |
| SCHEMBL9205112 | 0.88 | GRM2 (0.53) | MAOBGRM2 | |
| SCHEMBL8566870 | 0.88 | GRM2 (0.53) | MAOBGRM2 | |
| SCHEMBL16686266 | 0.80 | MAOA (0.64) | MAOAMAOBCALML3GRM2 | |
| SCHEMBL9205426 | 0.80 | MAOA (0.64) | MAOAMAOBCALML3GRM2 | |
| SCHEMBL9207736 | 0.77 | SLC6A2 (0.41) | MAOAMAOB | |
| SCHEMBL9210042 | 0.76 | GRM2 (0.52) | MAOBGRM2 | |
| SCHEMBL541746 | 0.75 | CALML3 (0.53) | MAOAMAOBCALML3 | |
| SCHEMBL541747 | 0.75 | CALML3 (0.53) | MAOAMAOBCALML3 | |
| SCHEMBL11220259 | 0.74 | GRM2 (0.55) | MAOAMAOBCALML3GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425209-B1 | Naphthyloxazolidone derivatives | TANABE SEIYAKU CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5332754-A | Antidepressant | TANABE SEIYAKU CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5182296-A | Antidepressants | TANABE SEIYAKY CO., LTD. (JP) | 1993-01-26 | — | — | US | disclosed |
| EP-0425209-A2 | Naphthyloxazolidone derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |