Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11721401 | 0.86 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL9878315 | 0.83 | — | — | |
| SCHEMBL354701 | 0.75 | HSD11B1 (0.39) | HSD11B1CYP2C9 | |
| SCHEMBL24300140 | 0.73 | ALDH1A1 (0.50) | LOXLOXL3LOXL2ALDH1A1TDP1 | |
| SCHEMBL24300508 | 0.73 | ALDH1A1 (0.50) | LOXLOXL3LOXL2ALDH1A1TDP1 | |
| SCHEMBL9214746 | 0.71 | ALDH1A1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL11726131 | 0.70 | ALDH1A1 (0.36) | LOXLOXL3LOXL2ALDH1A1TDP1 | |
| SCHEMBL24300507 | 0.68 | ALDH1A1 (0.33) | ALDH1A1TDP1 | |
| SCHEMBL7714492 | 0.67 | HSD11B1 (0.41) | HSD11B1CYP2C9 | |
| SCHEMBL2747594 | 0.67 | HSD11B1 (0.46) | HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500653-A4 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0500653-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |
| WO-1991006548-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST, INC. (US) | 1991-05-16 | — | — | WO | disclosed |
| US-5008265-A | 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same | BIOCRYST, INC. (US) | 1991-04-16 | — | — | US | disclosed |