Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208988 | 0.95 | HCN4 (0.41) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| SCHEMBL9207815 | 0.94 | HCN4 (0.40) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| Hydrochloric Acid SCHEMBL9740138 | 0.94 | CYP3A4 (0.41) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| SCHEMBL9205651 | 0.91 | HTR1A (0.38) | MAPTHTR1ASLC6A4DRD3SMN1; SMN2 | |
| SCHEMBL9214709 | 0.90 | HCN4 (0.41) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| SCHEMBL9210593 | 0.89 | HCN4 (0.40) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| SCHEMBL9207407 | 0.88 | HTR1A (0.37) | HTR1ASLC6A4DRD3SMN1; SMN2DRD4 | |
| SCHEMBL9211495 | 0.86 | HTR1A (0.42) | MAPTHTR1ASLC6A4SMN1; SMN2BCHE | |
| SCHEMBL9205217 | 0.86 | HCN4 (0.40) | HCN4MAPTCYP3A4ALOX15HTR1A | |
| SCHEMBL9213796 | 0.86 | MTNR1A (0.41) | HCN4MAPTCYP3A4ALOX15HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |