Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206684 | 0.95 | HTR1A (0.41) | HTR1ACHRNA7MTNR1ACRHBPCRHR2 | |
| SCHEMBL9215793 | 0.94 | HTR1A (0.39) | HTR1ACHRNA7MTNR1ACRHBPCRHR2 | |
| SCHEMBL9205651 | 0.90 | HTR1A (0.38) | HTR1ADRD2HTR2ASLC6A4HTR7 | |
| SCHEMBL9216989 | 0.90 | HTR1A (0.36) | HTR1AHTR7CHRNA7MTNR1ACRHBP | |
| SCHEMBL9215741 | 0.89 | HTR1A (0.38) | HTR1AHTR7CHRNA7CRHBPCRHR2 | |
| SCHEMBL9208546 | 0.88 | HCN4 (0.42) | HTR1ASLC6A4SMN1; SMN2DRD4DRD3 | |
| SCHEMBL9211495 | 0.85 | HTR1A (0.42) | HTR1ADRD2SLC6A4CHRNA7MTNR1A | |
| SCHEMBL9215882 | 0.85 | LTA4H (0.32) | HTR1A | |
| SCHEMBL9215232 | 0.84 | HTR1A (0.40) | HTR1ADRD2HTR2ASLC6A4CHRNA7 | |
| SCHEMBL9214406 | 0.84 | ATM (0.37) | DRD2SMN1; SMN2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |