Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204195 | 0.95 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL2817383 | 0.79 | NPC1 (0.50) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL9219292 | 0.78 | SOAT1 (0.48) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9219371 | 0.75 | LOXL2 (0.46) | ALDH1A1NPC1MAPTMEN1KMT2A | |
| SCHEMBL9211149 | 0.75 | NPC1 (0.46) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL9223497 | 0.72 | NPC1 (0.46) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL9203617 | 0.72 | NPC1 (0.46) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL12436884 | 0.71 | HSD17B10 (0.47) | ALDH1A1SMN1; SMN2NPC1MAPTMEN1 | |
| SCHEMBL6959797 | 0.69 | KDM4E (0.62) | ALDH1A1SMN1; SMN2GLANPC1MAPT | |
| SCHEMBL31535894 | 0.69 | MGLL (0.54) | ALDH1A1SMN1; SMN2GLANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662969-A1 | UREA AND THIOUREA DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-07-19 | — | — | EP | disclosed |
| WO-1995004053-A1 | UREA AND THIOUREA DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |