SCHEMBL9211149

SCHEMBL9211149

CC(=O)NCC1(c2ccc([N+](=O)[O-])cc2)OCC(C)(C)CO1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.46
ALDH1A1 P00352 4/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
GLA P06280 1/20 0.45
MAPT P10636 4/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
MAPK1 P28482 1/20 0.40
RECQL P46063 1/20 0.39
CYP1A2 P05177 1/20 0.39
GAA P10253 1/20 0.39
POLB P06746 2/20 0.38
HTR1E P28566 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
S1PR3 Q99500 1/20 0.38
RAB9A P51151 1/20 0.37
THRB P10828 1/20 0.37
TSHR P16473 1/20 0.36
EPHX1 P07099 1/20 0.36
NQO2 P16083 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9223497 0.82 NPC1 (0.46) NPC1ALDH1A1SMN1; SMN2GLAMAPT
SCHEMBL9203617 0.82 NPC1 (0.46) NPC1ALDH1A1SMN1; SMN2GLAMAPT
SCHEMBL9213960 0.80 SOAT1 (0.54) SMN1; SMN2KMT2AMEN1
SCHEMBL9220984 0.79 LOXL2 (0.42) NPC1ALDH1A1SMN1; SMN2MAPTKMT2A
SCHEMBL9223474 0.78 OPRM1 (0.37) ALDH1A1MAPTKMT2AMEN1CYP1A2
SCHEMBL2817383 0.78 NPC1 (0.50) NPC1ALDH1A1SMN1; SMN2GLAMAPT
SCHEMBL9208754 0.75 ALDH1A1 (0.49) NPC1ALDH1A1SMN1; SMN2GLAMAPT
SCHEMBL9204195 0.73 SMN1; SMN2 (0.47) NPC1ALDH1A1SMN1; SMN2GLAMAPT
SCHEMBL9203604 0.72 ALDH1A1 (0.43) NPC1ALDH1A1SMN1; SMN2MAPTKMT2A
SCHEMBL17596778 0.68 HSD17B10 (0.48) NPC1ALDH1A1SMN1; SMN2MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662969-A1 UREA AND THIOUREA DERIVATIVES AND PROCESS FOR THEIR PREPARATION PHARMACIA & UPJOHN S.p.A. (IT) 1995-07-19 EP disclosed
WO-1995004053-A1 UREA AND THIOUREA DERIVATIVES AND PROCESS FOR THEIR PREPARATION PHARMACIA S.P.A. (IT) 1995-02-09 WO disclosed