SCHEMBL920885

SCHEMBL920885

Nc1ncccc1C(=O)NCc1cccc(Oc2ccc(F)c(C(F)(F)F)c2)c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.47
KMT2A Q03164 1/20 0.47
CDK8 P49336 1/20 0.46
RPS6KB1 P23443 1/20 0.46
PPARG P37231 2/20 0.46
PPARD Q03181 2/20 0.46
PPARA Q07869 2/20 0.46
MAPK8 P45983 1/20 0.45
MAPK14 Q16539 2/20 0.45
KDM4E B2RXH2 1/20 0.44
USP2 O75604 1/20 0.44
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.44
FLT1 P17948 1/20 0.44
FLT4 P35916 1/20 0.44
KDR P35968 1/20 0.44
KLKB1 P03952 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921954 0.93 HPGD (0.47) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920883 0.92 RPS6KB1 (0.47) HPGDKMT2ACDK8RPS6KB1MAPK8
SCHEMBL921323 0.87 MAPK14 (0.57) HPGDKMT2APPARGPPARDPPARA
SCHEMBL921886 0.87 MAPK14 (0.50) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920195 0.86 MAPK14 (0.55) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920670 0.86 MAPK8 (0.53) HPGDKMT2AMAPK8MAPK14KDM4E
SCHEMBL922231 0.86 KMT2A (0.46) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920054 0.86 MAPK8 (0.48) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920254 0.85 MAPK14 (0.60) HPGDKMT2APPARGPPARDPPARA
SCHEMBL920754 0.85 KCNQ3 (0.51) HPGDKMT2APPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 HPGD 1273/4885KMT2A 2469/4885CDK8 3908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.