SCHEMBL920195

SCHEMBL920195

Nc1ncccc1C(=O)NCc1cccc(Oc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.55
PPARG P37231 8/20 0.51
PPARD Q03181 8/20 0.51
PPARA Q07869 8/20 0.51
HPGD P15428 3/20 0.50
KMT2A Q03164 2/20 0.50
KCNQ3 O43525 1/20 0.48
KCNQ2 O43526 1/20 0.48
LMNA P02545 1/20 0.48
MAPK8 P45983 1/20 0.48
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
DHFR P00374 1/20 0.48
USP2 O75604 1/20 0.47
ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921323 0.93 MAPK14 (0.57) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL919622 0.93 MAPK14 (0.54) MAPK14KMT2AMAPK8KDM4EMEN1
SCHEMBL923196 0.91 GPR52 (0.49) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL923670 0.90 LMNA (0.58) MAPK14HPGDKMT2ALMNAMEN1
SCHEMBL920754 0.89 KCNQ3 (0.51) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL921706 0.89 PPARG (0.54) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL920582 0.88 MAPK14 (0.58) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL1680406 0.87 MAPK8 (0.63) MAPK14HPGDKMT2AMAPK8KDM4E
SCHEMBL920254 0.87 MAPK14 (0.60) MAPK14PPARGPPARDPPARAHPGD
SCHEMBL921259 0.86 KMT2A (0.53) HPGDKMT2AMAPK8KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885PPARG 391/4885PPARD 360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.