Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37664 | 0.92 | HTR2A (0.62) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL11000854 | 0.88 | HTR2A (0.53) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL6645015 | 0.85 | RAB9A (0.61) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL9676749 | 0.85 | HTR2A (0.57) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL4725847 | 0.85 | HTR2A (0.59) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL1029307 | 0.85 | HTR2A (0.59) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL6141153 | 0.84 | HTR2A (0.59) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL10949489 | 0.84 | HTR2A (0.56) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL161797 | 0.83 | HTR2A (0.55) | HTR2AIDO1RAB9AAKR1C3HTT | |
| SCHEMBL10639376 | 0.83 | HTR2A (0.54) | HTR2AIDO1RAB9AAKR1C3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126587-B1 | Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof | SUMITOMO PHARMA (JP) | 1995-04-19 | — | — | EP | disclosed |
| US-5089489-A | Enzyme inhibitors | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-02-18 | — | — | US | disclosed |
| US-4954493-A | ENZYME INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0131374-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PENEM DERIVATIVES | PFIZER INC. (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4619783-A | BACTERICIDES | PFIZER INC. (US) | 1986-10-28 | — | — | US | disclosed |
| US-4539152-A | INTERMEDIATES FOR THIENAMYCIN ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-09-03 | — | — | US | disclosed |
| EP-0131374-A1 | Process and intermediates for the preparation of penem derivatives | PFIZER INC. (US) | 1985-01-16 | — | — | EP | disclosed |
| EP-0035689-B1 | 4-SUBSTITUTED-2-OXOAZETIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE FOR PREPARING ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-12-19 | — | — | EP | disclosed |
| EP-0089139-A2 | Antibiotics, their preparation and use | BEECHAM GROUP PLC (GB) | 1983-09-21 | — | — | EP | disclosed |
| US-4383945-A | 4-Substituted-2-oxoazetidine compounds and processes for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-05-17 | — | — | US | disclosed |
| EP-0035689-A1 | 4-Substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-09-16 | — | — | EP | disclosed |