Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26841823 | 0.75 | KDM4E (0.37) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL26709437 | 0.71 | LMNA (0.39) | POLBAPOBEC3G | |
| SCHEMBL9209139 | 0.71 | NCF1 (0.41) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL10200506 | 0.71 | JAK3 (0.35) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL9215459 | 0.71 | LMNA (0.35) | NOS3NOS2POLBAPOBEC3G | |
| SCHEMBL12503229 | 0.68 | NOS3 (0.41) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL10200515 | 0.67 | TTR (0.46) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL7942579 | 0.66 | PSMB5 (0.36) | — | |
| SCHEMBL11985899 | 0.65 | POLB (0.35) | NOS3NOS2POLBAPOBEC3GNOS1 | |
| SCHEMBL1427726 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520724-B1 | Angiotensin II antagonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5387592-A | Angiotensin converting enzyme inhibitors, calcium channel blockers, diuretics and adrenergic blocking agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-07 | — | — | US | disclosed |
| EP-0520723-B1 | Angiotensin II antagonists | ICI PLC (GB) | 1994-06-01 | — | — | EP | disclosed |
| US-5281613-A | Heterocyclic ring substituted benzofuran, benzothiofuran, or indole derivative | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0520723-A1 | Angiotensin II antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0520724-A1 | Angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |