SCHEMBL920984

SCHEMBL920984

Cc1cc(Oc2ccc(CN)cc2)cc(C)c1Cl

nearest known ligand 0.66

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ST14 Q9Y5Y6 3/20 0.66
KDM4E B2RXH2 1/20 0.44
MCL1 Q07820 5/20 0.43
MAOB P27338 5/20 0.43
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
KEAP1 Q14145 1/20 0.39
NFE2L2 Q16236 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15832064 0.84 ST14 (0.58) ST14KDM4EMCL1MAOBALDH1A1
SCHEMBL17149393 0.84 SMN1; SMN2 (0.46) ST14KDM4EMCL1SMN1; SMN2
SCHEMBL22440847 0.82 MCL1 (0.43) ST14KDM4EMCL1ALDH1A1SMN1; SMN2
SCHEMBL921340 0.81 ST14 (0.64) ST14MAOBALDH1A1SMN1; SMN2KEAP1
SCHEMBL21548254 0.79 ALDH1A1 (0.64) KDM4EMAOBALDH1A1SMN1; SMN2
SCHEMBL921403 0.79 ST14 (0.73) ST14MAOBALDH1A1
SCHEMBL920355 0.79 ST14 (0.73) ST14MAOBALDH1A1SMN1; SMN2KEAP1
SCHEMBL17147516 0.79 MCL1 (0.44) ST14KDM4EMCL1
SCHEMBL18184325 0.79 TEAD4 (0.50) KDM4EMCL1ALDH1A1SMN1; SMN2
SCHEMBL28478563 0.79 MAOA (0.50) KDM4EMCL1MAOBALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019040467-A1 SELECTIVE α-CYANOACRYLAMIDE AND α-CYANOACRYLATE INHIBTORS OF THE MCL-1 ONCOPROTEIN AND METHODS OF USING THE SAME UNIVERSITY OF MARYLAND, BALTIMORE (US) 2019-02-28 WO disclosed
WO-2019040467-A1 SELECTIVE α-CYANOACRYLAMIDE AND α-CYANOACRYLATE INHIBTORS OF THE MCL-1 ONCOPROTEIN AND METHODS OF USING THE SAME UNIVERSITY OF MARYLAND, BALTIMORE (US) 2019-02-28 WO disclosed
CN-101951771-A Composition for agricultural use for controlling or preventing plant diseases caused by plant pathogens SUMITOMO CHEMICAL CO 2011-01-19 CN disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-2009107764-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS 住友化学株式会社 (JP) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 ST14 708/4885KDM4E 3657/4885MCL1 4826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.