Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232798 | 0.87 | PTGS2 (0.58) | AOC3PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL9202698 | 0.86 | PTGS2 (0.60) | AOC3PTGS2PTGS1PGR | |
| SCHEMBL9208788 | 0.86 | PTGS2 (0.57) | AOC3PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL7467739 | 0.86 | PTGS2 (0.57) | AOC3PTGS2ALOX5CYP2C9PTGS1 | |
| Hydrochloric Acid SCHEMBL9740507 | 0.86 | PTGS2 (0.57) | AOC3PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL9203344 | 0.85 | PTGS2 (0.56) | AOC3PTGS2EPHX2ALOX5CYP2C9 | |
| SCHEMBL9203208 | 0.84 | PTGS2 (0.53) | AOC3PTGS2EPHX2ALOX5CYP2C9 | |
| SCHEMBL7240058 | 0.84 | PTGS2 (0.55) | AOC3PTGS2EPHX2ALOX5CYP2C9 | |
| SCHEMBL8923486 | 0.84 | RARA (0.59) | AOC3PTGS2ALOX5CYP2C9PTGS1 | |
| SCHEMBL9203630 | 0.83 | PTGS2 (0.65) | PTGS2ALOX5CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |