SCHEMBL9210163

SCHEMBL9210163

O=c1oc2ccccc2c(O)c1-c1ccc(C(F)(F)F)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.63
VKORC1 Q9BQB6 1/20 0.62
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
CYP1A2 P05177 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
CYP1A1 P04798 1/20 0.55
CYP2E1 P05181 1/20 0.55
CYP2C8 P10632 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2A6 P11509 1/20 0.55
CYP4B1 P13584 1/20 0.55
CYP2B6 P20813 1/20 0.55
CYP3A5 P20815 1/20 0.55
CYP2A7 P20853 1/20 0.55
CYP3A7 P24462 1/20 0.55
CYP2F1 P24903 1/20 0.55
CYP2C18 P33260 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11480111 0.84 MAOB (0.68) MAOBMEN1KMT2ACYP1A2CYP3A4
SCHEMBL29466790 0.83 MAOB (0.70) MAOBVKORC1MEN1KMT2ACYP1A2
SCHEMBL669375 0.83 MAOB (0.70) MAOBVKORC1MEN1KMT2ACYP1A2
SCHEMBL27790298 0.81 MAOB (0.72) MAOBMEN1KMT2ACYP1A2CYP3A4
SCHEMBL8934636 0.81 MAOB (0.68) MAOBMEN1KMT2ACYP1A2CYP3A4
SCHEMBL11480850 0.81 MAOB (0.68) MAOBVKORC1MEN1KMT2ACYP1A2
SCHEMBL24865054 0.78 MEN1 (0.67) VKORC1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL28592710 0.78 CYP1A1 (0.52) MAOBVKORC1MEN1KMT2ACYP1A2
SCHEMBL8335689 0.77 VKORC1 (0.69) VKORC1MEN1KMT2ACYP2C9KDM4E
SCHEMBL11485562 0.77 MAOB (1.00) MAOBVKORC1MEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0550493-B1 ANTHELMINTIC AND ANTICOCCIDAL 3-CARBAMOYL-4-HYDROXYCOUMARINS, METHOD OF USE AND COMPOSITIONS UPJOHN CO (US) 1995-08-09 EP disclosed
EP-0550493-A1 ANTHELMINTIC AND ANTICOCCIDAL 3-CARBAMOYL-4-HYDROXYCOUMARINS, METHOD OF USE AND COMPOSITIONS. UPJOHN CO (US) 1993-07-14 EP disclosed
WO-1992006083-A1 ANTHELMINTIC AND ANTICOCCIDAL 3-CARBAMOYL-4-HYDROXYCOUMARINS, METHOD OF USE AND COMPOSITIONS THE UPJOHN COMPANY (US) 1992-04-16 WO disclosed