SCHEMBL921031

SCHEMBL921031

Nc1ncccc1C(=O)NCc1cccc(O)c1F

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 1/20 0.49
LMNA P02545 1/20 0.47
MET P08581 1/20 0.46
PRKCI P41743 2/20 0.46
ADORA2A P29274 4/20 0.43
ADORA1 P30542 4/20 0.43
MAPK8 P45983 2/20 0.43
NAPRT Q6XQN6 1/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
PDPK1 O15530 1/20 0.43
PIK3CD O00329 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
ROCK1 Q13464 1/20 0.41
NSD2 O96028 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921659 0.83 HPGD (0.55) KLKB1LMNAMETADORA2AADORA1
SCHEMBL921483 0.83 LMNA (0.66) LMNAPRKCIADORA2AADORA1MAPK8
SCHEMBL920955 0.82 LMNA (0.56) KLKB1LMNAMETADORA2AADORA1
SCHEMBL920190 0.81 LMNA (0.49) KLKB1LMNAMETPRKCIADORA2A
SCHEMBL920578 0.81 MAPK8 (0.53) LMNAPRKCIMAPK8KDM4EALDH1A1
SCHEMBL921439 0.81 LMNA (0.47) KLKB1LMNAMETPRKCIADORA2A
SCHEMBL921438 0.81 LMNA (0.47) KLKB1LMNAMETPRKCIADORA2A
SCHEMBL920373 0.80 MAPK8 (0.45) KLKB1LMNAMETPRKCIADORA2A
SCHEMBL919407 0.80 LMNA (0.48) KLKB1LMNAMETADORA2AADORA1
SCHEMBL922791 0.80 MAPK8 (0.47) KLKB1LMNAMETPRKCIADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101951771-A Composition for agricultural use for controlling or preventing plant diseases caused by plant pathogens SUMITOMO CHEMICAL CO 2011-01-19 CN disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-2009107764-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS 住友化学株式会社 (JP) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 KLKB1 4691/4885LMNA 4812/4885MET 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.